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is administered intravenously, APS001F localizes and grows in the hypoxic regions of tumors, which results in expression of the CD enzyme in tumors. 5 FC, a commercially available anti fungal agent, which is administered orally, is converted to 5 FU, an active anti tumor agent, by the CD enzyme expressed by APS001F in tumors. The novel therapy is expected to have the advantage of limiting the systemic toxicity of 5 FU due to the local formation of 5 FU in tumors. It also allows 5 FU to achieve high concentration in tumors, which results in clear anti tumor efficacy.
About Tumor Hypoxia
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TOKYO, March 28, 2013 /PRNewswire/ Anaeropharma Science Inc. announced on March 28 that it has initiated a Phase I clinical trial of APS001F in patients with advanced solid tumors in the United States. The first in human dose escalation trial enrolls patients with advanced and/or metastatic solid tumors whose disease is no longer considered responsive to available treatments. Bifidobacterium is a non pathogenic obligate anaerobe and a major component of normal human intestinal flora. It is well known that the majority of human solid tumors contain hypoxic regions, mainly due to insufficient vascular formation. When APS001F Diesel Belt Buckle
candidates was invented by researchers at Shinshu University, Nagano, Japan.(Mr.) Tetsuya Mishima
BIND Biosciences, Inc. Selected for Oral Presentation of BIND 014 Clinical Data at American Association for Cancer Research 2013 Annual Meeting Data From Isis Pharmaceuticals, Inc. (ISIS) SMN Rx Phase 1 Study in Children With Spinal Muscular Atrophy Presented at the American Academy of Neurology Meeting
Anaeropharma is a biopharmaceutical company engaged in research and development of drug candidates that target hypoxic microenvironments of tumors by using recombinant bifidobacterium. This approach offers broad potential to be more effective to solid tumors and less toxic Armani Belt Womens
The majority of human solid tumors contain regions of acute or chronic hypoxia, mainly due Louis Vuitton Belt Cheap Uk to insufficient and unusual angiogenesis. Tumor hypoxia is a prognostic factor, commonly associated with aggressive tumor growth and poor survival rate. These microenvironments cause decreased uptake of chemotherapeutic drugs. Though many drugs and technologies exploiting tumor hypoxia have been explored in clinical trials, no effective anti cancer drugs or methods based on tumor hypoxia have been developed to date. A critical factor in the success of this strategy is the need to develop adequate delivery of anti cancer drugs targeting regions of tumor hypoxia. APS001F has great potential to achieve adequate delivery of the objective anti cancer drug.
to healthy tissues than conventional anti cancer drugs. The fundamental technology to create such drug Versace Belts For Sale
Anaeropharma Science Initiates First in Human Trial of Novel Recombinant Bifidobacterial Anti cancer Agent APS001F for Ad
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