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At least three people, including an eight year old boy, were killed when two bombs exploded in the crowded streets near the finish line of the Boston Marathon.
However, a White House official later said the explosions at one of the world's oldest and most prestigious races was being treated as terrorism.
He said investigators did not know precisely where the bombs were planted or whether they were hidden in mailboxes or rubbish bins.
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The first loud explosion occurred on the north side of Boylston Street, just before the photo bridge that marks the finish line. The second explosion could be heard a few seconds later.
At Massachusetts General Hospital, Alasdair Conn, chief of emergency services, said: ''This is something I've never seen in my 25 years here. Hermes Belt H Buckle
Additionally, Mr Obama spoke with Republican and Democratic leaders on Capitol Hill, saying that ''on days like this, there are no Republicans or Democrats, we are Americans united in our concern for our fellow citizens''.
The four hour mark is typically a highly crowded time near the finish line both because of the slow but steady recreational runners likely to be completing the race and because of all the relatives and friends clustered around to cheer them on.
They occurred about four hours into the race and two hours after the men's winner crossed the line. By that point, more than 17,000 of the runners had finished the race, but thousands of others were further back along the course.
Runners in the medical tent for treatment of dehydration or other race related ills were pushed out to make room for victims of the bombing.
A senior US intelligence official said the two other explosive devices found nearby were being dismantled.
''They just started bringing people in with no limbs,'' said runner Tim Davey, of Virginia. He said he and his wife, Lisa, tried to keep their children's eyes shielded from the gruesome scene inside a medical tent that had been set up to care for fatigued runners, but ''they saw a lot''.
Boston Police Commissioner Edward Davis asked people Gucci Belt Green Red Gold to stay indoors or go back to their hotel rooms and avoid crowds as bomb squads methodically checked parcels and bags left along the race route.
Some 23,000 runners took part in the race, which attracts more than 500,000 spectators and ends up in the heart of central Boston, near the landmark Prudential Centrerand the Boston Public Library. It is held on Patriots Day, a Massachusetts state holiday which commemorates the first battles of the American Revolution in 1775.
this amount of carnage in the civilian population. This is what we expect from war.''
The president was briefed on the incident by several senior administration officials, including FBI director Robert Mueller and Homeland Security Secretary Janet Napolitano. He also spoke with Massachusetts Governor Deval Patrick and Boston Mayor Tom Menino and pledged to provide whatever federal support was needed.
Many victims suffered lower leg injuries and shrapnel wounds. Some suffered ruptured eardrums.
Hospitals reported at least 144 people injured, at least 17 of them critically. The injuries ranged from cuts and bruises to amputations.
More than 140 other people were injured.
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Police said three people were killed. The eight year old boy had been waiting for his father to finish the race. His mother and sister were injured.
The twin blasts took place almost simultaneously and about 100 yards apart, knocking spectators and at least one runner off their feet, shattering windows and sending dense plumes of smoke rising over the street and through the fluttering national flags lining the course.
A few miles away from the finish line and around the same time, a fire broke out at the John F Kennedy presidential library. The police commissioner said it may have been caused by an incendiary device but did not appear to be related to the bombings.
As many as two unexploded bombs were also found near the end of the 26.2 mile (42km) course as part of what appeared to be a well co ordinated attack, but they were safely disarmed, according to a senior US intelligence official, who also spoke on condition of anonymity because of the continuing investigation.
WBZ TV reported hat law enforcement officers were searching an apartment in the Boston suburb of Revere. Massachusetts State Police confirmed that a search warrant related to the investigation into the explosions had been served in Revere but provided no further details.
US President Barack Obama, speaking from the White House, pointedly avoided using the words ''terror'' or ''terrorism'', saying that officials ''still do not know who did this or why''.
When the second bomb went off, the spectators' cheers turned to screams.
The Federal Aviation Administration created a no fly zone over the site of the explosions, and briefly ordered flights bound for Boston's Logan International Airport to be held on the ground at airports around the US.
who did this. We'll find out why they did this,'' Mr Obama said in his brief statement. Officials in Washington said there was no immediate claim of responsibility.
As sirens blared, emergency workers and National Guardsmen assigned to the race for crowd control began climbing over and tearing down temporary fences to get to the blast site.
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